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Previous Volume 350:1430-1441 April 1, 2004 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Ductal carcinoma in situ of the breast (also called intraductal carcinoma) consists of the clonal proliferation of cells that appear malignant and that accumulate within the lumens of the mammary duct. There is no evidence of invasion beyond the epithelial basement membrane into the adjacent breast stroma. This lesion, which is a precursor to invasive ductal carcinoma, is frequently diagnosed on screening mammography. In the past 20 years, concomitant with the wide use of screening mammography, the incidence of ductal carcinoma in situ has risen dramatically, and data from large cohort studies and randomized trials have emerged to guide treatment. . . . [Full Text of this Article]

Biologic Characteristics

Clinical and Pathological Features

Treatment

Clinical Management

Source Information

From the Division of Medical Oncology and the Departments of Medicine (H.J.B., K.P.), Radiation Oncology (J.S.W.), and Surgery (C.M.K.), Dana–Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School; and the Department of Pathology, Brigham and Women's Hospital and Harvard Medical School (S.C.L.) — all in Boston.

Address reprint requests to Dr. Burstein at the Dana–Farber Cancer Institute, 44 Binney St., Boston, MA 02115, or at hburstein@partners.org.

Related Letters:

Ductal Carcinoma in Situ of the Breast
Brown A. P., Ellison M. C., Kenney P. J., Kettritz U., Anderson W. F., Chu K. C., Burstein H. J., Wong J. S., Kaelin C. M.
Extract | Full Text | PDF  
N Engl J Med 2004; 351:399-402, Jul 22, 2004. Correspondence

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