In this issue of the Journal, Danesh and colleagues report thatelevated levels of C-reactive protein (CRP) are associated withonly a moderate increase in the risk of coronary heart disease(CHD).1 Although these findings are in line with those of otherlarge studies, the independent relative risk associated withincreased CRP levels is considerably less than in some earlierreports. Using a multivariate analysis, the authors found thatthe predictive value of CRP measurement adds relatively littleto that provided by assessments of traditional risk factors.In contrast, a smaller study suggested that the CRP level couldbe more . . . [Full Text of this Article]
Source Information
From the Division of Molecular Medicine, Department of Medicine, Columbia University Medical Center, New York.
Related Letters:
C-Reactive Protein and Coronary Heart Disease
Glynn R. J., Cook N. R., Libby P., Willerson J. T., Braunwald E., Foody J. M., Gotto A. M., Wenger N., Ridker P. M., Koenig W., Fuster V., Danesh J., Pepys M., Gudnason V.
Extract |
Full Text |
PDF
N Engl J Med 2004;
351:295-298, Jul 15, 2004.
Correspondence
This article has been cited by other articles:
Blumenthal, J. A, Sherwood, A., Rogers, S. D., Babyak, M. A., Murali Doraiswamy, P., Watkins, L., Hoffman, B. M., O'Connell, C., Johnson, J. J., Patidar, S. M., Waugh, R., Hinderliter, A.
(2007). Understanding prognostic benefits of exercise and antidepressant therapy for persons with depression and heart disease: the UPBEAT study rationale, design, and methodological issues. Clin Trials
4: 548-559
[Abstract]
Sinning, J.-M., Bickel, C., Messow, C.-M., Schnabel, R., Lubos, E., Rupprecht, H. J., Espinola-Klein, C., Lackner, K. J., Tiret, L., Munzel, T., Blankenberg, S., for the Athero Gene Investigators,
(2006). Impact of C-reactive protein and fibrinogen on cardiovascular prognosis in patients with stable angina pectoris: the AtheroGene study. Eur Heart J
27: 2962-2968
[Abstract][Full Text]
Vermeire, S, Van Assche, G, Rutgeerts, P
(2006). Laboratory markers in IBD: useful, magic, or unnecessary toys?. Gut
55: 426-431
[Full Text]
Miller, M., Zhan, M., Havas, S.
(2005). High Attributable Risk of Elevated C-Reactive Protein Level to Conventional Coronary Heart Disease Risk Factors: The Third National Health and Nutrition Examination Survey. Arch Intern Med
165: 2063-2068
[Abstract][Full Text]
Richards, A. M., Frampton, C. M.
(2005). N-Terminal-Pro-B-Type Natriuretic Peptide: Universal Marker of Cardiovascular Risk?. Circulation
112: 9-11
[Full Text]
Campbell, D. J., Woodward, M., Chalmers, J. P., Colman, S. A., Jenkins, A. J., Kemp, B. E., Neal, B. C., Patel, A., MacMahon, S. W.
(2005). Prediction of Myocardial Infarction by N-Terminal-Pro-B-Type Natriuretic Peptide, C-Reactive Protein, and Renin in Subjects With Cerebrovascular Disease. Circulation
112: 110-116
[Abstract][Full Text]
Glynn, R. J., Cook, N. R., Libby, P., Willerson, J. T., Braunwald, E., Foody, J. M., Gotto, A. M., Wenger, N., Ridker, P. M., Koenig, W., Fuster, V., Danesh, J., Pepys, M., Gudnason, V.
(2004). C-Reactive Protein and Coronary Heart Disease. NEJM
351: 295-298
[Full Text]