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Diarrhea is the most frequent health problem in travelers from industrialized countries who visit developing countries, especially in tropical areas of the world. The incidence of traveler's diarrhea ranges from 30 percent to 70 percent among short-term travelers, and incapacitation rates among such travelers are as high as 45 percent during travel to high-risk destinations; the rates drop dramatically at destinations with lower risk. Traveler's diarrhea has long been a problem for civilian and military travelers from industrialized countries because they often have no immunity to the pathogens to which they are exposed while traveling. The pathogens responsible for traveler's
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