FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 350:1814-1816 April 29, 2004 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Lossos, I. S. PubMed Citation

Clinical medicine is in the midst of a revolution that is being driven by an increasing understanding of the human genome and advances in molecular biotechnology. This revolution promises to transform clinical practice from population-based risk assessment and empirical treatment to a predictive, individualized model based on the molecular classification of disease and targeted therapy. The expectation is, of course, that personalized approaches to clinical care will increase the efficacy of treatment while decreasing its toxicity and cost.

Nowhere is this transformation more apparent than in oncology. Cancer is a complex disease. Our current taxonomy of cancers, which is based . . . [Full Text of this Article]

Source Information

From the Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston; and the Program in Cancer Genomics, Broad Institute, Cambridge, Mass.

This article has been cited by other articles:

• Lee, Y.-S., Chen, C.-H., Tsai, C.-N., Tsai, C.-L., Chao, A., Wang, T.-H. (2009). Microarray labeling extension values: laboratory signatures for Affymetrix GeneChips. Nucleic Acids Res 37: e61-e61 [Abstract] [Full Text]  
• Wang, R., Morris, D. S., Tomlins, S. A., Lonigro, R. J., Tsodikov, A., Mehra, R., Giordano, T. J., Kunju, L. P., Lee, C. T., Weizer, A. Z., Chinnaiyan, A. M. (2009). Development of a Multiplex Quantitative PCR Signature to Predict Progression in Non-Muscle-Invasive Bladder Cancer. Cancer Res. 69: 3810-3818 [Abstract] [Full Text]  
• Garman, K. S., Acharya, C. R., Edelman, E., Grade, M., Gaedcke, J., Sud, S., Barry, W., Diehl, A. M., Provenzale, D., Ginsburg, G. S., Ghadimi, B. M., Ried, T., Nevins, J. R., Mukherjee, S., Hsu, D., Potti, A. (2008). A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities. Proc. Natl. Acad. Sci. USA 105: 19432-19437 [Abstract] [Full Text]  
• Vachani, A., Nebozhyn, M., Singhal, S., Alila, L., Wakeam, E., Muschel, R., Powell, C. A., Gaffney, P., Singh, B., Brose, M. S., Litzky, L. A., Kucharczuk, J., Kaiser, L. R., Marron, J. S., Showe, M. K., Albelda, S. M., Showe, L. C. (2007). A 10-Gene Classifier for Distinguishing Head and Neck Squamous Cell Carcinoma and Lung Squamous Cell Carcinoma. Clin. Cancer Res. 13: 2905-2915 [Abstract] [Full Text]  
• Coudry, R. A., Meireles, S. I., Stoyanova, R., Cooper, H. S., Carpino, A., Wang, X., Engstrom, P. F., Clapper, M. L. (2007). Successful Application of Microarray Technology to Microdissected Formalin-Fixed, Paraffin-Embedded Tissue. J. Mol. Diagn. 9: 70-79 [Abstract] [Full Text]  
• Chen, H.-Y., Yu, S.-L., Chen, C.-H., Chang, G.-C., Chen, C.-Y., Yuan, A., Cheng, C.-L., Wang, C.-H., Terng, H.-J., Kao, S.-F., Chan, W.-K., Li, H.-N., Liu, C.-C., Singh, S., Chen, W. J., Chen, J. J.W., Yang, P.-C. (2007). A Five-Gene Signature and Clinical Outcome in Non-Small-Cell Lung Cancer. NEJM 356: 11-20 [Abstract] [Full Text]  
• Talantov, D., Baden, J., Jatkoe, T., Hahn, K., Yu, J., Rajpurohit, Y., Jiang, Y., Choi, C., Ross, J. S., Atkins, D., Wang, Y., Mazumder, A. (2006). A Quantitative Reverse Transcriptase-Polymerase Chain Reaction Assay to Identify Metastatic Carcinoma Tissue of Origin. J. Mol. Diagn. 8: 320-329 [Abstract] [Full Text]  
• Archer, K. J., Dumur, C. I., Joel, S. E., Ramakrishnan, V. (2006). Assessing quality of hybridized RNA in Affymetrix GeneChip experiments using mixed-effects models. Biostatistics 7: 198-212 [Abstract] [Full Text]  
• Breier, A. (2005). Developing Drugs for Cognitive Impairment in Schizophrenia. Schizophr Bull 31: 816-822 [Abstract] [Full Text]  
• Bibikova, M., Yeakley, J. M., Chudin, E., Chen, J., Wickham, E., Wang-Rodriguez, J., Fan, J.-B. (2004). Gene Expression Profiles in Formalin-Fixed, Paraffin-Embedded Tissues Obtained with a Novel Assay for Microarray Analysis. Clin. Chem. 50: 2384-2386 [Full Text]  
• (2004). Session 1: Metastasis. Toxicol Pathol 32: 730-731