FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 350:1906 April 29, 2004 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Domené, H. M. PubMed Citation

To the Editor: Domené et al. (Feb. 5 issue)¹ describe a boy with homozygous inactivation of the IGFALS gene, which encodes the acid-labile subunit (ALS) of insulin-like growth factor I (IGF-I) who had delayed puberty and moderate growth impairment. However, his height, when considered as a function of bone age, was only about 1 SD below the mean normal. The association of this gene defect with delayed puberty may prove fortuitous. In other rare cases, persons with inactivation of the IGFALS gene may not be considered short, and their total IGF-I may not be measured. Changes in height and progression . . . [Full Text of this Article]

This article has been cited by other articles:

• van Duyvenvoorde, H A, Kempers, M J E, Twickler, T. B, van Doorn, J, Gerver, W J, Noordam, C, Losekoot, M, Karperien, M, Wit, J M, Hermus, A R M M (2008). Homozygous and heterozygous expression of a novel mutation of the acid-labile subunit. Eur J Endocrinol 159: 113-120 [Abstract] [Full Text]