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Volume 350:1906-1908 April 29, 2004 Number 18
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The Budd–Chiari Syndrome

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by Menon, K.V. N.
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To the Editor: We would like to comment on the definitions and classification used in the comprehensive review of the Budd–Chiari syndrome by Menon et al. (Feb. 5 issue).1 Agreement on a uniform nomenclature is an essential requirement for clinical practice and future collaborative studies. Veno-occlusive disease, also referred to as the sinusoidal obstruction syndrome, is defined as nonthrombotic obstruction of sinusoids or central hepatic veins due to toxic injury of the sinusoidal wall.2 The epidemiology, pathophysiology, and treatment of veno-occlusive disease are so distinct from those of the Budd–Chiari syndrome that it is generally considered a separate disease entity.3 . . . [Full Text of this Article]



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