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Previous Volume 350:2000-2001 May 6, 2004 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: According to the report by Freedman et al. (Feb. 5 issue),¹ the median ratio of arachidonic acid to docosahexaenoic acid in patients with cystic fibrosis was higher than that in healthy subjects. Because linoleic acid is metabolized to arachidonic acid in humans, a deficiency in linoleic acid might cause increased metabolism of arachidonic acid. In cystic fibrosis cells expressing the F508 defect in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), the conversion of linoleic acid to arachidonic acid increased significantly as compared with that in cystic fibrosis cells transfected with the CFTR . . . [Full Text of this Article]

This article has been cited by other articles:

• Xu, Y., Liu, C., Clark, J. C., Whitsett, J. A. (2006). Functional Genomic Responses to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and CFTR{Delta}508 in the Lung. J. Biol. Chem. 281: 11279-11291 [Abstract] [Full Text]