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Volume 350:2003-2004 May 6, 2004 Number 19
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Circulating Angiogenic Factors and Preeclampsia

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by Levine, R. J.
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To the Editor: Levine et al. (Feb. 12 issue)1 have shown that increased levels of soluble fms-like tyrosine 1 (sFlt-1) and reduced levels of placental growth factor (PlGF) predict the development of preeclampsia, a few weeks before the onset of clinical symptoms. Circulating angiogenic factors produced by the placenta could therefore be used to predict preeclampsia. Since vascular endothelial growth factor (VEGF) levels did not differ significantly between the controls and the women who later had preeclampsia, attention has been focused on PlGF and sFlt-1 modifications. However, differences in free VEGF concentrations might have been underestimated because measurements were performed . . . [Full Text of this Article]



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