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Correspondence
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Volume 350:2006-2007 May 6, 2004 Number 19
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Parvovirus B19

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 by Young, N. S.
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To the Editor: We would like to add some information to Young and Brown's review (Feb. 5 issue)1 of parvovirus B19 infection and myocarditis. We studied myocardial tissue from five patients with fulminant parvovirus B19–associated myocarditis by in situ hybridization and showed that parvovirus B19 is present exclusively in endothelial cells of the smaller intramyocardial vessels (Figure 1A), not in cardiac myocytes.2 Additional immunohistochemical investigation revealed marked expression of E-selectin by endothelial cells of parvovirus B19–infected hearts, a finding indicative of endothelial dysfunction, and massive margination and adhesion of T lymphocytes in the venular compartment (Figure 1B. . . [Full Text of this Article]


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