A Comparison of Vasopressin and Epinephrine for Out-of-Hospital Cardiopulmonary Resuscitation
Volker Wenzel, M.D., Anette C. Krismer, M.D., H. Richard Arntz, M.D., Helmut Sitter, Ph.D., Karl H. Stadlbauer, M.D., Karl H. Lindner, M.D., for the European Resuscitation Council Vasopressor during Cardiopulmonary Resuscitation Study Group
Background Vasopressin is an alternative to epinephrine forvasopressor therapy during cardiopulmonary resuscitation, butclinical experience with this treatment has been limited.
Methods We randomly assigned adults who had had an out-of-hospitalcardiac arrest to receive two injections of either 40 IU ofvasopressin or 1 mg of epinephrine, followed by additional treatmentwith epinephrine if needed. The primary end point was survivalto hospital admission, and the secondary end point was survivalto hospital discharge.
From the Department of Anesthesiology and Critical Care Medicine, Leopold-Franzens University, Innsbruck, Austria (V.W., A.C.K., K.H.S., K.H.L.); the Department of Medicine, Division of CardiologyPulmonology, Benjamin Franklin Medical Center, Free University, Berlin, Germany (H.R.A.); and the Institute for Theoretical Surgery, Philipps University, Marburg, Germany (H.S.). Presented in part at the European Resuscitation Council Scientific Congress, Florence, Italy, October 35, 2002; and at the Scientific Sessions of the American Heart Association, Orlando, Fla., November 711, 2003.
Address reprint requests to Dr. Lindner at the Department of Anesthesiology and Critical Care Medicine, Leopold-Franzens University, Anichstr. 35, 6020 Innsbruck, Austria, or at volker.wenzel{at}uibk.ac.at.
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