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Clinical Implications of Basic Research
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Volume 350:187-188 January 8, 2004 Number 2
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Putting the Brakes on Cylindromatosis?
Sunil R. Lakhani, M.D.

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A man cannot become a competent surgeon without the full knowledge of human anatomy and physiology, and the physician without physiology and chemistry flounders along in an aimless fashion, never able to gain any accurate conception of disease, practicing a sort of popgun pharmacy, hitting now the malady and again the patient, he himself not knowing which.

— Sir William Osler (1849–1919)

In patients with familial cylindromatosis, or "turban tumors," numerous benign skin adnexal tumors develop, principally on the head and neck (Figure 1). This rare disorder is caused by a mutation of the CYLD gene and has . . . [Full Text of this Article]


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From the Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, and the Royal Marsden Hospital — both in London.




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