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Volume 350:2095-2096 May 13, 2004 Number 20
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Changing the Priority for HLA Matching in Kidney Transplantation

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by van Rood, J. J.
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by Roberts, J. P.
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To the Editor: Roberts and colleagues (Feb. 5 issue)1 report that matching at the HLA-DR locus has significant effects on the survival of cadaveric renal grafts, whereas matching at the HLA-A and B loci has only small effects. They conclude that the allocation of kidneys from cadaveric donors should be based on HLA-DR matching, an approach that would also reduce the existing racial imbalance. This conclusion is in full accord with the findings of a single-center study reported by one of us and our colleagues in the Journal in 1980,2 findings that were subsequently confirmed in a larger series of . . . [Full Text of this Article]



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