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Volume 350:2102-2104 May 13, 2004 Number 20
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Acute Chemical Emergencies

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by Kales, S. N.
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To the Editor: In their review of acute chemical emergencies, Kales and Christiani (Feb. 19 issue)1 mention intravenous dosages of nerve-agent antidotes, but not intramuscular autoinjectors: the MARK I kit (atropine, 2 mg, plus 2-pralidoxime chloride, 600 mg) and diazepam, 10 mg. Originally developed for military use, these autoinjectors are now stockpiled by civilian responders. Emergency physicians will probably see patients who have already been treated with them.

Benzodiazepines are the only anticonvulsant medications that are useful in patients with seizures from nerve agents. Trying the usual anticonvulsant drugs used for status epilepticus wastes valuable time. Although not specifically approved . . . [Full Text of this Article]



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