FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 350:2151-2158 May 20, 2004 Number 21 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Perspective by Hlatky, M. A. Editorial by Rogers, J. G. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background Patients with nonischemic dilated cardiomyopathy are at substantial risk for sudden death from cardiac causes. However, the value of prophylactic implantation of an implantable cardioverter–defibrillator (ICD) to prevent sudden death in such patients is unknown.

Methods We enrolled 458 patients with nonischemic dilated cardiomyopathy, a left ventricular ejection fraction of less than 36 percent, and premature ventricular complexes or nonsustained ventricular tachycardia. A total of 229 patients were randomly assigned to receive standard medical therapy, and 229 to receive standard medical therapy plus a single-chamber ICD.

Results Patients were followed for a mean (±SD) of 29.0±14.4 months. The mean left ventricular ejection fraction was 21 percent. The vast majority of patients were treated with angiotensin-converting–enzyme (ACE) inhibitors (86 percent) and beta-blockers (85 percent). There were 68 deaths: 28 in the ICD group, as compared with 40 in the standard-therapy group (hazard ratio, 0.65; 95 percent confidence interval, 0.40 to 1.06; P=0.08). The mortality rate at two years was 14.1 percent in the standard-therapy group (annual mortality rate, 7 percent) and 7.9 percent in the ICD group. There were 17 sudden deaths from arrhythmia: 3 in the ICD group, as compared with 14 in the standard-therapy group (hazard ratio, 0.20; 95 percent confidence interval, 0.06 to 0.71; P=0.006).

Conclusions In patients with severe, nonischemic dilated cardiomyopathy who were treated with ACE inhibitors and beta-blockers, the implantation of a cardioverter–defibrillator significantly reduced the risk of sudden death from arrhythmia and was associated with a nonsignificant reduction in the risk of death from any cause.

Source Information

From the Clinical Cardiology Trials Office, Division of Cardiology, Department of Medicine, Northwestern University Medical School, Chicago (A.K., A.D., R.Q., J.G., A. Schaechter); the University of Rochester Medical Center, Rochester, N.Y. (J.P.D.); New England Medical Center, Boston (N.A.M.E.); Marshfield Clinic, Marshfield, Wisc. (K.P.A.); Johns Hopkins Hospital, Baltimore (H.C.); St. Francis Hospital, Roslyn, N.Y. (D.H., J.H.L.); the University of North Carolina at Chapel Hill, Chapel Hill (W.E.S.); and the Veterans Affairs Pittsburgh Healthcare System, Pittsburgh (A. Shalaby).

Address reprint requests to Dr. Kadish at 251 E. Huron, Feinberg 8-536, Chicago, IL 60611, or at a-kadish{at}northwestern.edu.

Full Text of this Article

This article has been cited by other articles:

• Authors/Task Force Members, , Dickstein, K., Cohen-Solal, A., Filippatos, G., McMurray, J. J.V., Ponikowski, P., Poole-Wilson, P. A., Stromberg, A., van Veldhuisen, D. J., Atar, D., Hoes, A. W., Keren, A., Mebazaa, A., Nieminen, M., Priori, S. G., Swedberg, K., ESC Committee for Practice Guidelines (CPG), , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Filippatos, G., Funck-Brentano, C., Hellemans, I., Kristensen, S. D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J. L., Document Reviewers, , Tendera, M., Auricchio, A., Bax, J., Bohm, M., Corra, U., della Bella, P., Elliott, P. M., Follath, F., Gheorghiade, M., Hasin, Y., Hernborg, A., Jaarsma, T., Komajda, M., Kornowski, R., Piepoli, M., Prendergast, B., Tavazzi, L., Vachiery, J.-L., Verheugt, F. W. A., Zamorano, J. L., Zannad, F. (2008). ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 29: 2388-2442 [Full Text]  
• Gronefeld, G. C. (2008). Discrimination of ventricular tachycardia from supraventricular tachycardia in implantable cardioverter defibrillators by automated electrogram morphology analysis: can leads finally replace the electrophysiologist?. Europace 10: 1131-1132 [Full Text]  
• Tung, R., Zimetbaum, P., Josephson, M. E. (2008). A Critical Appraisal of Implantable Cardioverter-Defibrillator Therapy for the Prevention of Sudden Cardiac Death. J Am Coll Cardiol 52: 1111-1121 [Abstract] [Full Text]  
• Epstein, A. E. (2008). Benefits of the Implantable Cardioverter-Defibrillator. J Am Coll Cardiol 52: 1122-1127 [Abstract] [Full Text]  
• Goldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., Stevenson, W. G., Zipes, D. P. (2008). American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death: A Scientific Statement From the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention. J Am Coll Cardiol 52: 1179-1199 [Full Text]  
• Goldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., Stevenson, W. G., Zipes, D. P. (2008). American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death: A Scientific Statement From the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention. Circulation 118: 1497-1518 [Full Text]  
• Ding, L., Hua, W., Niu, H., Chen, K., Zhang, S. (2008). Primary prevention of sudden cardiac death using implantable cardioverter defibrillators. Europace 10: 1034-1041 [Abstract] [Full Text]  
• Schefer, T., Wolber, T., Binggeli, C., Holzmeister, J., Brunckhorst, C., Duru, F. (2008). Long-term predictors of mortality in ICD patients with non-ischaemic cardiac disease: impact of renal function. Europace 10: 1052-1059 [Abstract] [Full Text]  
• Witte, K. K., Pepper, C. B., Cowan, J. C., Thomson, J. D., English, K. M., Blackburn, M. E. (2008). Implantable cardioverter-defibrillator therapy in adult patients with tetralogy of Fallot. Europace 10: 926-930 [Abstract] [Full Text]  
• Weinsaft, J. W., Kim, H. W., Shah, D. J., Klem, I., Crowley, A. L., Brosnan, R., James, O. G., Patel, M. R., Heitner, J., Parker, M., Velazquez, E. J., Steenbergen, C., Judd, R. M., Kim, R. J. (2008). Detection of Left Ventricular Thrombus by Delayed-Enhancement Cardiovascular Magnetic Resonance: Prevalence and Markers in Patients With Systolic Dysfunction. J Am Coll Cardiol 52: 148-157 [Abstract] [Full Text]  
• Jansen, A., Mischi, M., Bracke, F., van Dantzig, J. m., Peels, K., Lamfers, E., van Hemel, N., Korsten, H. (2008). Novel ultrasound contrast agent dilution method for the assessment of ventricular ejection fraction. Eur J Echocardiogr 9: 489-493 [Abstract] [Full Text]  
• Wu, K. C., Weiss, R. G., Thiemann, D. R., Kitagawa, K., Schmidt, A., Dalal, D., Lai, S., Bluemke, D. A., Gerstenblith, G., Marban, E., Tomaselli, G. F., Lima, J. A.C. (2008). Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy.. J Am Coll Cardiol 51: 2414-2421 [Abstract] [Full Text]  
• Pavri, B. B., Hillis, M. B., Subacius, H., Brumberg, G. E., Schaechter, A., Levine, J. H., Kadish, A., for the Defibrillators in Nonischemic Cardiomyopat, (2008). Prognostic Value and Temporal Behavior of the Planar QRS-T Angle in Patients With Nonischemic Cardiomyopathy. Circulation 117: 3181-3186 [Abstract] [Full Text]  
• Nishii, M., Inomata, T., Takehana, H., Naruke, T., Yanagisawa, T., Moriguchi, M., Takeda, S., Izumi, T. (2008). Prognostic utility of B-type natriuretic peptide assessment in stable low-risk outpatients with nonischemic cardiomyopathy after decompensated heart failure.. J Am Coll Cardiol 51: 2329-2335 [Abstract] [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N.A. M. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol 51: e1-e62 [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Mark Estes, N.A. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices) Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. J Am Coll Cardiol 51: 2085-2105 [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N.A. M. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation 117: 2820-2840 [Full Text]  
• Epstein, A. E., DiMarco, J. P., Ellenbogen, K. A., Estes, N.A. M. III, Freedman, R. A., Gettes, L. S., Gillinov, A. M., Gregoratos, G., Hammill, S. C., Hayes, D. L., Hlatky, M. A., Newby, L. K., Page, R. L., Schoenfeld, M. H., Silka, M. J., Stevenson, L. W., Sweeney, M. O. (2008). ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): Developed in Collaboration With the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation 117: e350-e408 [Full Text]  
• Eckstein, J., Koller, M. T., Zabel, M., Kalusche, D., Schaer, B. A., Osswald, S., Sticherling, C. (2008). Necessity for Surgical Revision of Defibrillator Leads Implanted Long-Term: Causes and Management. Circulation 117: 2727-2733 [Abstract] [Full Text]  
• Carroll, D. L., Hamilton, G. A. (2008). Long-term Effects of Implanted Cardioverter-Defibrillators on Health Status, Quality of Life, and Psychological State. Am J Crit Care 17: 222-230 [Abstract] [Full Text]  
• Gibson, D. P., Kuntz, K. K., Levenson, J. L., Ellenbogen, K. A. (2008). Decision-making, emotional distress, and quality of life in patients affected by the recall of their implantable cardioverter defibrillator. Europace 10: 540-544 [Abstract] [Full Text]  
• Moss, A. J. (2008). Life Versus Death. Circulation 117: 1912-1913 [Full Text]  
• Koller, M. T., Schaer, B., Wolbers, M., Sticherling, C., Bucher, H. C., Osswald, S. (2008). Death Without Prior Appropriate Implantable Cardioverter-Defibrillator Therapy: A Competing Risk Study. Circulation 117: 1918-1926 [Abstract] [Full Text]  
• Daubert, J. P., Zareba, W., Cannom, D. S., McNitt, S., Rosero, S. Z., Wang, P., Schuger, C., Steinberg, J. S., Higgins, S. L., Wilber, D. J., Klein, H., Andrews, M. L., Hall, W. J., Moss, A. J., for the MADIT II Investigators, (2008). Inappropriate Implantable Cardioverter-Defibrillator Shocks in MADIT II: Frequency, Mechanisms, Predictors, and Survival Impact. J Am Coll Cardiol 51: 1357-1365 [Abstract] [Full Text]  
• Albert, N. M., Lewis, C. (2008). Recognizing and Managing Asymptomatic Left Ventricular Dysfunction: After Myocardial Infarction. Crit Care Nurse 28: 20-37 [Full Text]  
• Stamato, N. J. (2008). Implantable Cardioverter-Defibrillators, Heart Failure, and Patient Characteristics. JAMA 299: 285-285 [Full Text]  
• Goldenberg, I., Vyas, A. K., Hall, W. J., Moss, A. J., Wang, H., He, H., Zareba, W., McNitt, S., Andrews, M. L., for the MADIT-II Investigators, (2008). Risk Stratification for Primary Implantation of a Cardioverter-Defibrillator in Patients With Ischemic Left Ventricular Dysfunction. J Am Coll Cardiol 51: 288-296 [Abstract] [Full Text]  
• Dickfeld, T., Lei, P., Dilsizian, V., Jeudy, J., Dong, J., Voudouris, A., Peters, R., Saba, M., Shekhar, R., Shorofsky, S. (2008). Integration of Three-Dimensional Scar Maps for Ventricular Tachycardia Ablation With Positron Emission Tomography-Computed Tomography. J Am Coll Cardiol Img 1: 73-82 [Abstract] [Full Text]  
• Rossenbacker, T., Priori, S. G., Zipes, D. P. (2007). The fight against sudden cardiac death: consensus guidelines as a reference. Eur Heart J Suppl 9: I50-I58 [Abstract] [Full Text]  
• Jung, W., Schumacher, B. (2007). What is the role of risk stratification for sudden death in the defibrillator era?. Eur Heart J Suppl 9: I59-I65 [Abstract] [Full Text]  
• Kanjwal, Y., Imran, N., Kanjwal, K., Grubb, B. (2007). Piggy-back pacing: implantation of pacemaker and defibrillator on top of each other. Europace 9: 1191-1193 [Abstract] [Full Text]  
• Passman, R., Subacius, H., Ruo, B., Schaechter, A., Howard, A., Sears, S. F., Kadish, A. (2007). Implantable Cardioverter Defibrillators and Quality of Life: Results From the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation Study. Arch Intern Med 167: 2226-2232 [Abstract] [Full Text]  
• Verrier, R. L., Kumar, K., Josephson, M. E. (2007). The Frustrating Search for Arrhythmia Risk Stratifiers in Heart Failure Due to Nonischemic Cardiomyopathy: Does T-Wave Alternans Testing Help?. J Am Coll Cardiol 50: 1905-1906 [Full Text]  
• Salerno-Uriarte, J. A., De Ferrari, G. M., Klersy, C., Pedretti, R. F.E., Tritto, M., Sallusti, L., Libero, L., Pettinati, G., Molon, G., Curnis, A., Occhetta, E., Morandi, F., Ferrero, P., Accardi, F., for the ALPHA Study Group Investigators, (2007). Prognostic Value of T-Wave Alternans in Patients With Heart Failure Due to Nonischemic Cardiomyopathy: Results of the ALPHA Study. J Am Coll Cardiol 50: 1896-1904 [Abstract] [Full Text]  
• Rossi, A., Cicoira, M., Bonapace, S., Golia, G., Zanolla, L., Franceschini, L., Vassanelli, C. (2007). Left atrial volume provides independent and incremental information compared with exercise tolerance parameters in patients with heart failure and left ventricular systolic dysfunction. Heart 93: 1420-1425 [Abstract] [Full Text]  
• Fleisher, L. A., Beckman, J. A., Brown, K. A., Calkins, H., Chaikof, E. L., Fleischmann, K. E., Freeman, W. K., Froehlich, J. B., Kasper, E. K., Kersten, J. R., Riegel, B., Robb, J. F., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Buller, C. E., Creager, M. A., Ettinger, S. M., Faxon, D. P., Fuster, V., Halperin, J. L., Hiratzka, L. F., Hunt, S. A., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., Tarkington, L. G., Yancy, C. W. (2007). ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) Developed in Collaboration With the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. J Am Coll Cardiol 50: e159-e242 [Full Text]  
• Fleisher, L. A., Beckman, J. A., Brown, K. A., Calkins, H., Chaikof, E. L., Fleischmann, K. E., Freeman, W. K., Froehlich, J. B., Kasper, E. K., Kersten, J. R., Riegel, B., Robb, J. F. (2007). ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). Circulation 116: e418-e500 [Full Text]  
• Authors/Task Force Members, , Vardas, P. E., Auricchio, A., Blanc, J.-J., Daubert, J.-C., Drexler, H., Ector, H., Gasparini, M., Linde, C., Morgado, F. B., Oto, A., Sutton, R., Trusz-Gluza, M., ESC Committee for Practice Guidelines (CPG), , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Funck-Brentano, C., Filippatos, G., Hellemans, I., Kristensen, S. D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J. L., Document Reviewers, , Priori, S. G., Blomstrom-Lundqvist, C., Brignole, M., Terradellas, J. B., Camm, J., Castellano, P., Cleland, J., Farre, J., Fromer, M., Le Heuzey, J.-Y., Lip, G. Y., Merino, J. L., Montenero, A. S., Ritter, P., Schalij, M. J., Stellbrink, C. (2007). Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in Collaboration with the European Heart Rhythm Association. Europace 9: 959-998 [Full Text]  
• Vassallo, P., Trohman, R. G. (2007). Prescribing Amiodarone: An Evidence-Based Review of Clinical Indications. JAMA 298: 1312-1322 [Abstract] [Full Text]  
• Authors/Task Force Members, , Vardas, P. E., Auricchio, A., Blanc, J.-J., Daubert, J.-C., Drexler, H., Ector, H., Gasparini, M., Linde, C., Morgado, F. B., Oto, A., Sutton, R., Trusz-Gluza, M., ESC Committee for Practice Guidelines (CPG), , Vahanian, A., Camm, J., De Caterina, R., Dean, V., Dickstein, K., Funck-Brentano, C., Filippatos, G., Hellemans, I., Kristensen, S. D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Zamorano, J. L., Document Reviewers, , Priori, S. G., Blomstrom-Lundqvist, C., Brignole, M., Terradellas, J. B., Camm, J., Castellano, P., Cleland, J., Farre, J., Fromer, M., Le Heuzey, J.-Y., Lip, G. Y., Merino, J. L., Montenero, A. S., Ritter, P., Schalij, M. J., Stellbrink, C. (2007). Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in Collaboration with the European Heart Rhythm Association. Eur Heart J 28: 2256-2295 [Full Text]  
• Singh, S., Murawski, M. M. (2007). Implantable Cardioverter Defibrillator Therapy and the Need for Concomitant Antiarrhythmic Drugs. J CARDIOVASC PHARMACOL THER 12: 175-180 [Abstract]  
• Hohnloser, S. H., Prystowsky, E. N. (2007). CRT-D use in heart failure: too little or too much?. Eur Heart J Suppl 9: G9-G16 [Abstract] [Full Text]  
• Ezekowitz, J. A., Rowe, B. H., Dryden, D. M., Hooton, N., Vandermeer, B., Spooner, C., McAlister, F. A. (2007). Systematic Review: Implantable Cardioverter Defibrillators for Adults with Left Ventricular Systolic Dysfunction. ANN INTERN MED 147: 251-262 [Abstract] [Full Text]  
• Passman, R., Kadish, A. (2007). Sudden Death Prevention With Implantable Devices. Circulation 116: 561-571 [Full Text]  
• Maron, B. J., Spirito, P., Shen, W.-K., Haas, T. S., Formisano, F., Link, M. S., Epstein, A. E., Almquist, A. K., Daubert, J. P., Lawrenz, T., Boriani, G., Estes, N. A. M. III, Favale, S., Piccininno, M., Winters, S. L., Santini, M., Betocchi, S., Arribas, F., Sherrid, M. V., Buja, G., Semsarian, C., Bruzzi, P. (2007). Implantable Cardioverter-Defibrillators and Prevention of Sudden Cardiac Death in Hypertrophic Cardiomyopathy. JAMA 298: 405-412 [Abstract] [Full Text]  
• Iacoviello, M., Forleo, C., Guida, P., Romito, R., Sorgente, A., Sorrentino, S., Catucci, S., Mastropasqua, F., Pitzalis, M. (2007). Ventricular Repolarization Dynamicity Provides Independent Prognostic Information Toward Major Arrhythmic Events in Patients With Idiopathic Dilated Cardiomyopathy. J Am Coll Cardiol 50: 225-231 [Abstract] [Full Text]  
• Zareba, W. (2007). Holter Electrocardiogram Parameters in Risk Stratification of Arrhythmic Events in Idiopathic Dilated Cardiomyopathy: More Studies Are Needed. J Am Coll Cardiol 50: 232-233 [Full Text]  
• Klingenheben, T. (2007). Microvolt T-Wave Alternans for Arrhythmia Risk Stratification in Left Ventricular Dysfunction: Which Patients Benefit?. J Am Coll Cardiol 50: 174-175 [Full Text]  
• Simpson, C. S. MD (2007). Implantable cardioverter defibrillators work so why aren't we using them?. CMAJ 177: 49-51 [Full Text]  
• Chugh, S. S., Reinier, K., Stecker, E. C. (2007). Learning From a Real-World Analysis of Implantable Cardioverter-Defibrillator Recipients: Comorbidities Matter. J Am Coll Cardiol 49: 2416-2418 [Full Text]  
• Lee, D. S., Tu, J. V., Austin, P. C., Dorian, P., Yee, R., Chong, A., Alter, D. A., Laupacis, A. (2007). Effect of Cardiac and Noncardiac Conditions on Survival After Defibrillator Implantation. J Am Coll Cardiol 49: 2408-2415 [Abstract] [Full Text]  
• Kloner, R. A., Cannom, D. S. (2007). Uncertainty on the Use of Aldosterone Antagonists for Primary Therapy for Sudden Cardiac Death in the Setting of Implanted Devices. Circulation 115: 2983-2989 [Full Text]  
• Patel, J., Heywood, J. T. (2007). Mode of Death in Patients With Systolic Heart Failure. J CARDIOVASC PHARMACOL THER 12: 127-136 [Abstract]  
• Juhn, P., Phillips, A., Buto, K. (2007). Balancing Modern Medical Benefits And Risks. Health Aff (Millwood) 26: 647-652 [Abstract] [Full Text]  
• Ermis, C., Zhu, A. X., VanHeel, L., Sakaguchi, R.N. S., Lurie, K. G., Lu, F., Benditt, D. G. (2007). Comparison of ventricular arrhythmia burden, therapeutic interventions, and survival, in patients < 75 and patients >= 75 years of age treated with implantable cardioverter defibrillators. Europace 9: 270-274 [Abstract] [Full Text]  
• Epstein, A. E., Baessler, C. A., Curtis, A. B., Estes, N.A. M. III, Gersh, B. J., Grubb, B., Mitchell, L. B. (2007). Addendum to "Personal and Public Safety Issues Related to Arrhythmias That May Affect Consciousness: Implications for Regulation and Physician Recommendations: A Medical/ Scientific Statement From the American Heart Association and the North American Society of Pacing and Electrophysiology" Public Safety Issues in Patients With Implantable Defibrillators A Scientific Statement From the American Heart Association and the Heart Rhythm Society. Circulation 115: 1170-1176 [Abstract] [Full Text]  
• Piotrowicz, K., Noyes, K., Lyness, J. M., McNitt, S., Andrews, M. L., Dick, A., Hall, W. J., Moss, A. J., Zareba, W. (2007). Physical functioning and mental well-being in association with health outcome in patients enrolled in the Multicenter Automatic Defibrillator Implantation Trial II. Eur Heart J 28: 601-607 [Abstract] [Full Text]  
• Wu, A. H (2007). Management of patients with non-ischaemic cardiomyopathy. Heart 93: 403-408 [Full Text]  
• Lindenfeld, J., Feldman, A. M., Saxon, L., Boehmer, J., Carson, P., Ghali, J. K., Anand, I., Singh, S., Steinberg, J. S., Jaski, B., DeMarco, T., Mann, D., Yong, P., Galle, E., Ecklund, F., Bristow, M. (2007). Effects of Cardiac Resynchronization Therapy With or Without a Defibrillator on Survival and Hospitalizations in Patients With New York Heart Association Class IV Heart Failure. Circulation 115: 204-212 [Abstract] [Full Text]  
• Goldenberg, I., Moss, A. J. (2007). Reply. J Am Coll Cardiol 49: 125-125 [Full Text]  
• Saxon, L. A., Bristow, M. R., Boehmer, J., Krueger, S., Kass, D. A., De Marco, T., Carson, P., DiCarlo, L., Feldman, A. M., Galle, E., Ecklund, F. (2006). Predictors of Sudden Cardiac Death and Appropriate Shock in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Trial. Circulation 114: 2766-2772 [Abstract] [Full Text]  
• Benditt, D. G., on behalf of the Ad Hoc Syncope Consortium, (2006). The ACCF/AHA Scientific Statement on Syncope: a document in need of thoughtful revision. Europace 8: 1017-1021 [Abstract] [Full Text]  
• Kramer, C. M. (2006). The Expanding Prognostic Role of Late Gadolinium Enhanced Cardiac Magnetic Resonance. J Am Coll Cardiol 48: 1986-1987 [Full Text]  
• Assomull, R. G., Prasad, S. K., Lyne, J., Smith, G., Burman, E. D., Khan, M., Sheppard, M. N., Poole-Wilson, P. A., Pennell, D. J. (2006). Cardiovascular Magnetic Resonance, Fibrosis, and Prognosis in Dilated Cardiomyopathy. J Am Coll Cardiol 48: 1977-1985 [Abstract] [Full Text]  
• Goldberger, J. J., Subacius, H., Schaechter, A., Howard, A., Berger, R., Shalaby, A., Levine, J., Kadish, A. H., for the DEFINITE Investigators, (2006). Effects of Statin Therapy on Arrhythmic Events and Survival in Patients With Nonischemic Dilated Cardiomyopathy. J Am Coll Cardiol 48: 1228-1233 [Abstract] [Full Text]  
• Developed in Collaboration With the European Heart, , Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L. (2006). ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 48: 1064-1108 [Full Text]  
• Developed in Collaboration With the European Heart, , Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B., Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L. (2006). ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 48: e247-e346 [Full Text]  
• Zipes, D. P., Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., ESC Committee for Practice Guidelines, , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L., ACC/AHA (Practice Guidelines) Task Force Members, , Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2006). ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society.. Eur Heart J 27: 2099-2140 [Full Text]  
• Luyster, F. S., Hughes, J. W., Waechter, D., Josephson, R. (2006). Resource loss predicts depression and anxiety among patients treated with an implantable cardioverter defibrillator.. Psychosom. Med. 68: 794-800 [Abstract] [Full Text]  
• Writing Committee Members, , Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., Chaitman, B., Fromer, M., Gregoratos, G., Klein, G., Moss, A. J., Myerburg, R. J., Priori, S. G., Quinones, M. A., Roden, D. M., Silka, M. J., Tracy, C., ESC Committee for Practice Guidelines, , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, A. J., Dean, V., Deckers, J. W., Despres, C., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J. L., Zamorano, J. L., ACC/AHA Task Force Members, , Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Antman, E. M., Anderson, J. L., Hunt, S. A., Halperin, J. L., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2006). ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace 8: 746-837 [Full Text]  
• Klein, G., Lissel, C., Fuchs, A.-C., Gardiwal, A., Oswald, H., deSousa, M., Pichlmaier, A. M., Lichtinghagen, R., Geerlings, H., Lippolt, P., Niehaus, M., Drexler, H., Korte, T. (2006). Predictors of VT/VF-occurrence in ICD patients: results from the PROFIT-Study.. Europace 8: 618-624 [Abstract] [Full Text]