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Correspondence
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Volume 350:2417-2419 June 3, 2004 Number 23
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Estrogen plus Progestin and Colorectal Cancer in Postmenopausal Women

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by Chlebowski, R. T.
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To the Editor: Chlebowski and colleagues (March 4 issue)1 claim that "short-term use" of progestin and estrogen reduces the risk of invasive colorectal cancer. For a valid conclusion regarding prevention, we need to know how many of the 115 women with invasive cancer were currently taking hormones and the total duration of use for any reason.

Most of the women in the placebo group had taken hormones: 10.7 percent started taking them during the trial, 25.6 percent had taken them previously (12.3 percent of whom had taken them for 10 years or more), and 42.5 percent had previously used oral . . . [Full Text of this Article]



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