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Previous Volume 350:2419-2421 June 3, 2004 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Petersen et al. (Feb. 12 issue)¹ provide further evidence that insulin resistance is associated with a reduction in mitochondrial function in muscle² and an increase in lipid content.³ They propose that mitochondrial dysfunction causes lipid accumulation and insulin resistance, but the relation among these variables is probably more complex. For example, insulin can increase mitochondrial transcript levels, protein synthesis, and ATP production in healthy people but not in people with type 2 diabetes.^4,5 Thus, one could argue that insulin signaling is required for maintenance of muscle mitochondria and that insulin resistance results in mitochondrial dysfunction, rather than . . . [Full Text of this Article]

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