Pneumocystis pneumonia remains the most prevalent opportunisticinfection in patients infected with the human immunodeficiencyvirus (HIV).1,2 First identified as a protozoan nearly 100 yearsago and reclassified as a fungus in 1988, pneumocystis cannotbe propagated in culture.3,4,5,6 Few treatment options existfor patients with pneumocystis pneumonia. The number of patientswho are receiving chronic immunosuppressive medication or whohave an altered immune system and are thus at risk for pneumocystispneumonia is rapidly growing.2 Although the prevalence of theacquired immunodeficiency syndrome (AIDS) has decreased in theWestern hemisphere owing to the routine use of highly activeantiretroviral . . . [Full Text of this Article]
Clinical Features of Pneumocystis Pneumonia
Diagnosis of Pneumocystis Infection
Prophylaxis and Treatment of Pneumocystis Pneumonia
Epidemiologic Features of Pneumocystis Pneumonia
The Biology of the Parasite
Host Response to Pneumocystis Infection
Lymphocyte Responses to Pneumocystis
Macrophages in Host Defense against Pneumocystis
Cytokine and Chemokine Networks
Alveolar Epithelial Cells and Proteins
Summary
Source Information
From the Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine (C.F.T., A.H.L.), and the Department of Biochemistry and Molecular Biology (A.H.L.), Mayo Clinic College of Medicine, Rochester, Minn.
Address reprint requests to Dr. Limper at 8-24 Stabile Bldg., Mayo Clinic, Rochester, MN 55905, or at limper.andrew@mayo.edu.
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Pneumocystis Pneumonia
del Rio C., Barragan M., Franco-Paredes C., Udwadia Z. F., Doshi A. V., Bhaduri A. S., van Well G., van Furth M.
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N Engl J Med 2004;
351:1262-1263, Sep 16, 2004.
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