The majority of drugs developed for neurologic indications failbecause they are not clinically tolerated. A sensible strategy,therefore, is to explore the efficacy of drugs in the nervoussystem that have already been approved for other indications.When I was in medical school, erythropoietin was known to bea cytokine produced in the kidney and was thought to be importantonly for the development of red cells, which bear receptorsfor erythropoietin. But recent results have shown that nervecells also have erythropoietin receptors and that this cytokineis made in the nervous system and can function as a . . . [Full Text of this Article]
Source Information
From the Burnham Institute, the Salk Institute for Biological Studies, the Scripps Research Institute, and the University of California at San Diego all in La Jolla.
Zandi, M. S, Coles, A. J
(2007). Notes on the kidney and its diseases for the neurologist. J. Neurol. Neurosurg. Psychiatry
78: 444-449
[Abstract][Full Text]
Djaiani, G. N.
(2006). Aortic arch atheroma: stroke reduction in cardiac surgical patients.. SEMIN CARDIOTHORAC VASC ANESTH
10: 143-157
[Abstract]
Khuntia, D., Brown, P., Li, J., Mehta, M. P.
(2006). Whole-Brain Radiotherapy in the Management of Brain Metastasis. JCO
24: 1295-1304
[Abstract][Full Text]
Watanabe, D., Suzuma, K., Matsui, S., Kurimoto, M., Kiryu, J., Kita, M., Suzuma, I., Ohashi, H., Ojima, T., Murakami, T., Kobayashi, T., Masuda, S., Nagao, M., Yoshimura, N., Takagi, H.
(2005). Erythropoietin as a Retinal Angiogenic Factor in Proliferative Diabetic Retinopathy. NEJM
353: 782-792
[Abstract][Full Text]
Zhang, D., Zhang, G., Hayden, M.S., Greenblatt, M.B., Bussey, C., Flavell, R.A., Gosh, S., Leist, M., Ghezzi, P., Grasso, G., Bianchi, R., Villa, P., Fratelli, M., Savino, C., Bianchi, M., Nielsen, J., Gerwien, J., Kallunki, P., Larsen, A., Helboe, L., Christensen, S., Pedersen, L., Nielsen, M., Torup, L., Sager, T.H., Sfacteria, A., Erbayaktar, S., Erbayaktar, Z., Gokmen, N., Yilmaz, O., Cerami-Hand, C., Xie, Q., Coleman, T.H., Cerami, A., Brines, M., Torres, V. E., Wang, X., Quian, Q., Somlo, S. T., Harris, P., Gattone, V.
(2005). A Novel Molecule Designed to Keep Bacteria out of the Urinary Tract: A Toll-Like Receptor that Prevents Infection by Uropathogenic Bacteria. Science 303: 1522-1526, 2004. J. Am. Soc. Nephrol.
16: 4-7
[Full Text]
Roesler, R., Quevedo, J., Schroder, N., Lipton, S. A.
(2004). Erythropoietin, Glutamate, and Neuroprotection. NEJM
351: 1465-1466
[Full Text]