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Previous Volume 350:2521-2522 June 10, 2004 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We commend Gladwin et al. (Feb. 26 issue)¹ on their large prospective study of pulmonary hypertension in the population of patients with sickle cell disease. The pathogenesis of pulmonary hypertension in sickle cell disease remains unclear and is probably multifactorial. In general, elevated pulmonary-artery pressures occur most commonly because of left-sided heart disease, a well-described complication of sickle cell disease.² Consequently, pulmonary hypertension has been defined as a mean pulmonary-artery pressure of 25 mm Hg at rest and a pulmonary-capillary wedge pressure of less than 15 mm Hg.³ The 18 patients who underwent catheterization had a mean . . . [Full Text of this Article]

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• Anthi, A., Machado, R. F., Jison, M. L., Taveira-DaSilva, A. M., Rubin, L. J., Hunter, L., Hunter, C. J., Coles, W., Nichols, J., Avila, N. A., Sachdev, V., Chen, C. C., Gladwin, M. T. (2007). Hemodynamic and Functional Assessment of Patients with Sickle Cell Disease and Pulmonary Hypertension. Am. J. Respir. Crit. Care Med. 175: 1272-1279 [Abstract] [Full Text]