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Correspondence
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Volume 350:2623-2624 June 17, 2004 Number 25
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Case 7-2004: Hereditary Melanoma and Pancreatic Cancer

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by Tsao, H.
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To the Editor: The discussants in Case 7-2004 (Feb. 26 issue)1 comprehensively review hereditary melanoma arising from inherited CDKN2A mutations, but they fail to mention the increased risk of pancreatic cancer associated with germ-line CDKN2A mutations.2,3 Although pancreatic cancer did not occur in the pedigree of the patient in this case, its absence could reflect the early death of affected family members. Carriers of germ-line CDKN2A mutations affecting the p16 protein have been estimated to have a 17 percent lifetime risk of pancreatic cancer.4 To help prevent premature death from pancreatic cancer, persons with an increased susceptibility to this cancer, . . . [Full Text of this Article]



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