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Images in Clinical Medicine
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Volume 350:2698 June 24, 2004 Number 26
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Vitiligo and Pernicious Anemia

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A 45-year-old woman with a 17-year history of vitiligo (panel A) was evaluated because of persistent fatigue. She was found to have pancytopenia (white-cell count, 3200 per cubic millimeter; hemoglobin level, 8.1 g per deciliter; and platelet count, 147,000 per cubic millimeter) with macrocytosis (mean corpuscular volume, 125 µm3) and hypersegmented polymorphonuclear leukocytes (Panel B; hematoxylin and eosin, x100). The serum vitamin B12 level was 84 pmol per liter (normal range, 220 to 660). The serum folate level was normal. Erythroid hyperplasia with left-shifted megaloblastic erythropoiesis and giant metamyelocytes (Panel C, arrow; hematoxylin and eosin, x100) was . . . [Full Text of this Article]

 



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