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Previous Volume 350:2721-2722 June 24, 2004 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Jerome and Corey (Jan. 22 issue)¹ comment on the identification of urate crystals as an immunologic danger signal released from apoptotic cells in mice, as shown in part by the ability of purified urate crystals to induce maturation of dendritic cells in vitro (when cultured in 10 percent fetal-calf serum).² Inconsistent with this proposed signal is the finding that humans lacking xanthine oxidase, and hence urate, have no known immunologic disorder.³ Because mice and cattle (but not humans) express urate oxidase (uricase), we wondered whether the hydrogen peroxide produced by uricase in fetal-calf serum might be responsible . . . [Full Text of this Article]

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