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Images in Clinical Medicine
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Volume 350:e24 June 24, 2004 Number 26
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Homozygous Hemoglobin C Disease

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A Ghanaian child was found on routine screening to have a hemoglobin level of 9.0 g per deciliter, a hematocrit of 24.3 percent, a mean corpuscular volume of 53.8 µm3, a red-cell distribution width of 28.8 percent, and an uncorrected reticulocyte count of 1.6 percent. There were no signs of splenomegaly. Testing of the father, who was asymptomatic, revealed only hemoglobin C on electrophoresis and a complete blood count similar to that of the child. A blood smear showed a constellation of findings that were characteristic of homozygous hemoglobin C disease: target cells (arrows), microspherocytes (arrowheads), rod-shaped cells containing . . . [Full Text of this Article]

 

Related Letters:

Hemoglobin C Disease
Schwab J. G., Abelson H. T., Fairhurst R. M., Casella J. F.
Extract | Full Text | PDF  
N Engl J Med 2004; 351:1577, Oct 7, 2004. Correspondence

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