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Previous Volume 350:379-392 January 22, 2004 Number 4 Next

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In 2004, an estimated 173,700 Americans will receive a diagnosis of lung cancer, and 164,440 of them will die of the disease. Despite years of research, the prognosis for patients with lung cancer remains dismal, with a five-year survival rate of 14 percent. Nevertheless, lung cancer may be curable in its early stages, and most patients derive some benefit from treatment such as longer survival or amelioration of symptoms. The topic was last reviewed in the Journal in 1992.¹ This review will focus on the multidisciplinary management and treatment of lung cancer, with particular emphasis on phase 3 studies.

Figure . . . [Full Text of this Article]

Principles of Radiotherapy in Lung Cancer

General Approach to Chemotherapy

Non–Small-Cell Lung Cancer

Staging and Evaluation

Surgery

Adjuvant Therapy

            Radiotherapy

            Chemotherapy

Neoadjuvant Therapy

            Nonresectable Tumors

            Resectable Tumors

            Advanced Disease

Small-Cell Lung Cancer

Limited Disease

Extensive Disease

Summary and Future Directions

Source Information

From the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore.

Address reprint requests to Dr. Ettinger at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting Blaustein Cancer Research Bldg., Rm. G88, 1650 Orleans St., Baltimore, MD 21231-1000, or at ettinda@jhmi.edu.

Related Letters:

Multidisciplinary Management of Lung Cancer
Jacobson B. C., Gould M. K., Silvestri G. A., Detterbeck F., Papagiannis A., Buyukcelik A., Yalcin B., Utkan G., Spira A., Ettinger D. S.
Extract | Full Text | PDF  
N Engl J Med 2004; 350:2008-2010, May 6, 2004. Correspondence

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