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Previous Volume 350:411-412 January 22, 2004 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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But I must go and meet with danger there,

Or it will seek me in another place,

And find me worse provided.

— William Shakespeare, Henry IV

We come into contact with a vast assortment of external agents every day, and our immune system needs to deal with them. How does the immune system distinguish dangerous from nonthreatening situations? Many pathogens contain chemical signatures, such as lipopolysaccharide, that are not present in human cells. These exogenous danger signals interact with a variety of cellular receptors to trigger the maturation of antigen-presenting cells, especially tissue- and lymphoid-based dendritic cells. The mature . . . [Full Text of this Article]

Source Information

From the Department of Laboratory Medicine, University of Washington; and the Program in Infectious Diseases, Fred Hutchinson Cancer Research Center — both in Seattle.

Related Letters:

The Danger Within
Gu Y., Hershfield M. S., Cohen A., Jerome K. R., Corey L.
Extract | Full Text | PDF  
N Engl J Med 2004; 350:2721-2722, Jun 24, 2004. Correspondence

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