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Volume 350:516-518 January 29, 2004 Number 5
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Prognostic Value of Myeloperoxidase in Patients with Chest Pain

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 by Manolio, T.
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 by Brennan, M.-L.
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To the Editor: Brennan et al. (Oct. 23 issue)1 report an intriguing study of myeloperoxidase in the evaluation of patients with acute chest pain. However, the use of a test for clinical prediction also requires decisions about the sensitivity and specificity of any selected cutoff point.2 The only information of this type provided in the article is the evaluation of the creatine kinase MB isoform (CK-MB), C-reactive protein, and myeloperoxidase for the prediction of major cardiac events within 30 days in patients with chest pain and normal troponin T levels. When the sensitivities and specificities are combined into likelihood ratios, . . . [Full Text of this Article]


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