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Previous Volume 350:537-538 February 5, 2004 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The first known description of hemoglobinuria — urine the color of a cola beverage — appears in a 13th-century text, the De Urinis of Johannes Zacharias (Actuarius), physician to the court of Byzantium. Zacharias, the first person to use a graduated cylinder for urinalysis, had probably recorded a rare complication of falciparum malaria, one known as blackwater fever. In the centuries after the conquest of Constantinople, other causes of black urine were uncovered, but none were more fascinating than paroxysmal nocturnal hemoglobinuria (PNH).

PNH has a particular resonance in Boston for two reasons. One is that the first diagnostic test . . . [Full Text of this Article]

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