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Previous Volume 350:570-577 February 5, 2004 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The growth-promoting actions of growth hormone were originally hypothesized to be mediated through a circulating liver-generated sulfation factor that later came to be known as insulin-like growth factor I (IGF-I).¹ This growth factor is produced in almost every tissue in the body.² In the cartilage growth plate, growth hormone–induced IGF-I³ acts locally through autocrine–paracrine mechanisms.⁴

Some 80 to 85 percent of IGF-I circulates as a 150-kD ternary complex that includes the ligand itself, IGF-binding protein 3, and an acid-labile subunit.⁵ The acid-labile subunit is a glycoprotein found almost exclusively in the circulation and produced in the liver under growth hormone . . . [Full Text of this Article]

Case Report

Methods

Endocrine Studies

Western Ligand Blotting and Western Immunoblotting

Size-Exclusion Chromatography

Molecular Studies

Results

Discussion

Source Information

From the Endocrinology Research Center, Division of Endocrinology, Ricardo Gutiérrez Children's Hospital (H.M.D., A.S.M., M.G.R., P.P., P.S., J.J.H., H.G.J.); and the Division of Pediatrics, J.A. Fernández Hospital (S.V.B.) — both in Buenos Aires, Argentina.

Address reprint requests to Mr. Domené at the Endocrinology Research Center (CEDIE), Division of Endocrinology, Ricardo Gutiérrez Children's Hospital, Gallo 1330, 1425 Buenos Aires, Argentina, or at hdomene@cedie.org.ar.

Related Letters:

Circulating IGF-I Deficiency and Inactivation of the Acid-Labile Subunit Gene
Daughaday W. H., Domené H. M., Martínez A. S., Jasper H. G.
Extract | Full Text | PDF  
N Engl J Med 2004; 350:1906, Apr 29, 2004. Correspondence

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