FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 350:605-607 February 5, 2004 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Freedman, S. D. PubMed Citation

In 1989, when the gene locus for cystic fibrosis was identified, expectations were great for rapid progress in understanding and effectively treating the disease. It was generally believed that cystic fibrosis was a monogenic disease, which would possibly soon be treatable by gene therapy. Now, 15 years later, it has turned out that nature is much more complicated than we had predicted. For example, even though more than 1200 mutations have been identified in the cystic fibrosis transmembrane conductance regulator gene (CFTR), the search for a relation between the different phenotypes and mutations has mainly failed. Furthermore, siblings . . . [Full Text of this Article]

Source Information

From the Department of Pediatrics, Institute of the Health of Women and Children, Göteborg University, Göteborg, Sweden.

This article has been cited by other articles:

• Erskine, J. M., Lingard, C., Sontag, M. (2007). Update on Enteral Nutrition Support for Cystic Fibrosis. Nutr Clin Pract 22: 223-232 [Abstract] [Full Text]  
• Beharry, S., Ackerley, C., Corey, M., Kent, G., Heng, Y.-M., Christensen, H., Luk, C., Yantiss, R. K., Nasser, I. A., Zaman, M., Freedman, S. D., Durie, P. R. (2007). Long-term docosahexaenoic acid therapy in a congenic murine model of cystic fibrosis. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G839-G848 [Abstract] [Full Text]  
• Xu, Y., Liu, C., Clark, J. C., Whitsett, J. A. (2006). Functional Genomic Responses to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and CFTR{Delta}508 in the Lung. J. Biol. Chem. 281: 11279-11291 [Abstract] [Full Text]  
• Olson, D. L., Schwenk, W. F. II (2004). Nutrition for Patients With Cystic Fibrosis. Nutr Clin Pract 19: 575-580 [Abstract] [Full Text]  
• Kida, Y., Steger, B., Colvin, H. P., Laposata, M., O'Sullivan, B. P., Freedman, S. D. (2004). Eicosanoids in Cystic Fibrosis. NEJM 350: 2000-2001 [Full Text]