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Clinical Implications of Basic Research
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Volume 350:614-615 February 5, 2004 Number 6
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Getting a Handle on Graft-versus-Host Disease
Robertson Parkman, M.D.

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A central dichotomy of allogeneic hematopoietic stem-cell transplantation for neoplastic diseases is that the immune responses initiated by donor-derived cells provide both the chief benefit and the major limitation of the therapy. The benefit is the graft-versus-tumor (GVT) effect, and the limitation is graft-versus-host disease (GVHD). Edinger and his colleagues1 have reported a method for overcoming the limitation. They prevented GVHD while preserving the GVT effect in a mouse model of lymphoma by including CD4+CD25+ regulatory T lymphocytes in the inoculum of hematopoietic stem cells.

The immune response represents the net effect of factors that stimulate the immune system and . . . [Full Text of this Article]


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From the Saban Research Institute, Children's Hospital, Los Angeles.



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