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Volume 350:619-621 February 5, 2004 Number 6
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First-Trimester Screening for Down's Syndrome

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by Mennuti, M. T.
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by Wapner, R.
-PubMed Citation
To the Editor: Wapner and colleagues (Oct. 9 issue)1 describe implementation of the first-trimester combined test for trisomies 21 and 18 in 8514 women with a singleton pregnancy. They compare the performance of the Down's syndrome screening test (a detection rate of 79 percent with a false positive rate of 5 percent) with published estimates for the second-trimester triple and quadruple tests but not with the integrated test, although they cite the article describing the integrated test.2 They overlook the superior screening performance of the integrated test, which uses late first-trimester and early second-trimester markers together to obtain one screening . . . [Full Text of this Article]



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