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Previous Volume 350:732-733 February 12, 2004 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Glatzel et al. (Nov. 6 issue)¹ report extraneural localization of pathologic prion protein (PrP^Sc) in patients with sporadic Creutzfeldt–Jakob disease. They report that PrP^Sc could be identified in spleen and muscle specimens from approximately one third of patients with this disease. It would be interesting to search for PrP^Sc in the peripheral nervous system in these patients, particularly those with PrP^Sc in skeletal muscle. A previous immunohistochemical study showed the accumulation of prion protein in the dorsal roots of a patient with sporadic Creutzfeldt–Jakob disease.² Using immunohistochemistry and Western blot analyses in seven cases of sporadic . . . [Full Text of this Article]

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• Head, M W, Peden, A H, Yull, H M, Ritchie, D L, Bonshek, R E, Tullo, A B, Ironside, J W (2005). Abnormal prion protein in the retina of the most commonly occurring subtype of sporadic Creutzfeldt-Jakob disease. Br J Ophthalmol 89: 1131-1138 [Abstract] [Full Text]