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Volume 350:836-838 February 19, 2004 Number 8
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Hemofiltration and the Prevention of Radiocontrast-Agent–Induced Nephropathy

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by Marenzi, G.
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To the Editor: Marenzi et al. (Oct. 2 issue)1 offer a provocative article on the role of hemofiltration in preventing radiocontrast-agent–induced nephropathy. We disagree with the assumption that a lower creatinine concentration in the hemofiltration group, relative to the control group, implies less renal dysfunction, since hemofiltration itself lowers the creatinine concentration. We wonder why hemofiltration, with its low clearance of radiocontrast material, should have prevented nephropathy, since many believe that renal injury occurs on initial exposure to radiocontrast material,2 and particularly since hemofiltration was stopped during the procedure and restarted after contrast injection. In theory the timing of hemofiltration . . . [Full Text of this Article]



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