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Previous Volume 350:860-861 February 26, 2004 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In 1997, a Swiss Company (Berna Biotech) received approval to market an inactivated influenza vaccine for parenteral administration that consists of the hemagglutinin and neuraminidase surface antigens of influenzavirus incorporated into liposomes. This virosome vaccine was subsequently used in the formulation of an influenzavirus vaccine for intranasal administration. To optimize both mucosal and systemic immune responses to the nasal vaccine, heat-labile Escherichia coli enterotoxin, one of the most powerful mucosal adjuvants known, was included in the formulation. The clinical studies showed that clinically significant antibody responses to influenzavirus were elicited by this vaccine, as evidenced in both nasopharyngeal secretions and . . . [Full Text of this Article]

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From the Baylor College of Medicine, Houston.

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