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Previous Volume 351:108 July 1, 2004 Number 1

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By Karen Rader. 299 pp., illustrated. Princeton, N.J., Princeton University Press, 2004. $45. ISBN 0-691-01636-4.

Karen Rader has written a valuable book. The story is that of inbred mice — their development, their adoption as the favored organism of mammalian geneticists, and the distribution system that arose to provide the research community with a variety of strains and mutants. It is also very much the story of one man and one institution. The man was Clarence Cook "Prexy" Little, who initiated the development of inbred mice in 1909 while working as an undergraduate at Harvard's Bussey Institution. Later, Little's passionate drive and influence were instrumental in gaining acceptance of genetically standardized mouse models. The Jackson . . . [Full Text of this Article]

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