Cutaneous melanoma remains a management challenge. The NationalCancer Institute Surveillance, Epidemiology, and End Results(SEER) database documents increases of 619 percent in annualdiagnoses of cutaneous melanoma and of 165 percent in annualmortality from 1950 to 2000.1 In 2004, an estimated 55,000 Americanswill receive a diagnosis of cutaneous melanoma, and 7900 willdie from the disease.2 Of all cancers in the United States,cutaneous melanoma ranks fifth in incidence among men and seventhamong women2 and is the second leading cause of lost productiveyears3,4; it is also the most common cancer among women 20 to. . . [Full Text of this Article]
Melanoma Screening and Identification of High-Risk Persons
Identification of High-Risk Lesions
Staging and Treatment of Primary Melanoma
Nodal Sampling and Staging
Adjuvant Therapy
Treatment of Distant Disease
Future Directions
Source Information
From the Department of Dermatology (H.T., A.J.S.), Massachusetts General Hospital Melanoma Center (H.T., A.J.S.), and the Wellman Center for Photomedicine (H.T.), Massachusetts General Hospital and Harvard Medical School; and the Division of Hematology/Oncology, Department of Medicine, Biologic Therapy and Cutaneous Oncology Programs, Beth Israel Deaconess Medical Center and Harvard Medical School (M.B.A.) all in Boston.
Address reprint requests to Dr. Tsao at the Department of Dermatology, Massachusetts General Hospital, Bartlett 622, 48 Blossom St., Boston, MA 02114.
Related Letters:
Management of Cutaneous Melanoma
de Giorgi V., Carli P., Giannotti B., Sampsel J. W., Barbera-Guillem E., Miranda E. P., Tsao H., Atkins M. B., Sober A. J.
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N Engl J Med 2004;
351:2770-2771, Dec 23, 2004.
Correspondence
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