FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 351:1053-1056 September 9, 2004 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Ray, W. A. PubMed Citation

All drugs have the potential to cause adverse effects. Occasionally, serious adverse effects are not identified in preclinical studies and become apparent only when a drug is in widespread clinical use — a particular problem with adverse events that are rare and result in few symptoms. One example of relevance to clinicians and regulatory agencies is drug-induced prolongation of the QT interval. During the past few years, many drugs have been removed from the market or required to include "black box" warnings on their labels because of the potential for QT-interval prolongation. The list of causative medications is daunting, and . . . [Full Text of this Article]

Source Information

From the Department of Medicine, University of Toronto (B.A.L., D.N.J.); and the Divisions of Geriatric Medicine (B.A.L.), General Internal Medicine (D.N.J.), and Clinical Pharmacology (B.A.L., D.N.J.), Sunnybrook and Women's College Health Sciences Centre — both in Toronto.

Related Letters:

Oral Erythromycin and the Risk of Sudden Death
Kaplan E. L., Winston A. P., Schoenholtz J. C., Harris J.-D., de Leon-Casasola O. A., Amory J. K., Amory D. W. Sr., Ray W. A., Murray K. T., Stein C. M., Liu B. A., Juurlink D. N.
Extract | Full Text | PDF  
N Engl J Med 2005; 352:301-304, Jan 20, 2005. Correspondence

This article has been cited by other articles:

• Zemrak, W. R., Kenna, G. A. (2008). Association of antipsychotic and antidepressant drugs with Q-T interval prolongation. Am J Health Syst Pharm 65: 1029-1038 [Abstract] [Full Text]  
• Jackson, C. W., Sheehan, A. H., Reddan, J. G. (2007). Evidence-based review of the black-box warning for droperidol. Am J Health Syst Pharm 64: 1174-1186 [Abstract] [Full Text]  
• Baker, J. R, Best, A. M, Pade, P. A, McCance-Katz, E. F (2006). Effect of Buprenorphine and Antiretroviral Agents on the QT Interval in Opioid-Dependent Patients. The Annals of Pharmacotherapy 40: 392-396 [Abstract] [Full Text]  
• Wyatt, J P, Lee, J (2005). JournalScan. Emerg. Med. J. 22: 362-363 [Full Text]  
• Kaplan, E. L., Winston, A. P., Schoenholtz, J. C., Harris, J.-D., de Leon-Casasola, O. A., Amory, J. K., Amory, D. W. Sr., Ray, W. A., Murray, K. T., Stein, C. M., Liu, B. A., Juurlink, D. N. (2005). Oral erythromycin and the risk of sudden death.. NEJM 352: 301-304 [Full Text]  
• (2004). Erythromycin and Sudden Death. JWatch General 2004: 2-2 [Full Text]