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Volume 351:1263-1264 September 16, 2004 Number 12
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Hereditary Hemochromatosis

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by Pietrangelo, A.
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To the Editor: Dr. Pietrangelo (June 3 issue)1 proposes that a liver biopsy be performed for diagnosis of suspected adult-onset hereditary hemochromatosis when first-line genetic testing does not reveal typical mutations and serum ferritin is persistently elevated. Two articles published this year2,3 show that magnetic resonance imaging (MRI) provides a useful and noninvasive diagnostic tool for quantification of hepatic iron concentrations. Gandon et al.2 found that a highly T2-weighted gradient-echo sequence was most sensitive, permitting detection of all clinically relevant cases of hepatic iron overload that exceeded 60 µmol per gram of liver, dry weight. We have used the . . . [Full Text of this Article]



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