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Previous Volume 351:1465-1466 September 30, 2004 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Lipton (June 10 issue)¹ discusses the possible cellular mechanisms and pathways underlying the neuroprotective effects of erythropoietin in neurologic disorders such as stroke and diabetic neuropathy. Given the key role of glutamate-mediated excitotoxicity in the pathophysiology of stroke and other neurologic conditions, we believe that it is important to address the possibility that a decrease in neuronal glutamate release is a critical mechanism underlying the neuroprotective actions of erythropoietin. For instance, there is evidence that the protective effects of erythropoietin from ischemia-induced neuronal death in cultured hippocampal neurons is mediated by a reduction in glutamate release from . . . [Full Text of this Article]

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