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A correction has been published: N Engl J Med 2005;352(5):524.

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Volume 351:1490-1492 October 7, 2004 Number 15
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Genotypes and Phenotypes — Another Lesson from the Hemoglobinopathies
Edward J. Benz, Jr., M.D.

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by Geva, A.
-PubMed Citation
The human genome project has ignited considerable excitement about the future of medicine by revealing insights into diseases that seemed impossible to unravel only a few years ago. But knowledge of genes and proteins cannot by itself explain clinical phenomena — for this, molecular genetics requires the context of pathophysiology. The puzzling ways in which diseases manifest themselves in individual patients serve as a reminder that using genomics to improve clinical medicine will not be easy.

The report by Geva and colleagues in this issue of the Journal (pages 1532–1538) illustrates nicely how an astute combination of molecular biology and . . . [Full Text of this Article]


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From the Dana–Farber Cancer Institute, Boston.



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