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Correspondence
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Volume 351:1691-1692 October 14, 2004 Number 16
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Oxaliplatin in Colon Cancer

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by André, T.
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To the Editor: André et al. (June 3 issue)1 report that adding oxaliplatin to a regimen of fluorouracil plus leucovorin (FL) improves the adjuvant treatment of colon cancer. With regard to patients with stage II disease, previous studies have indicated that obstruction of the colon by tumor, the total number of lymph nodes examined, carcinoembryonic antigen levels, perforation, and the tumor grade can identify patients at high risk for recurrence.2,3 If one considers Figure 3 of the article by André et al., patients with these risk factors seemed to receive little benefit. It is not clear from this study how . . . [Full Text of this Article]



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