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During the past two decades, the rate of diagnosis of primary central nervous system lymphoma has more than doubled. Yet even though nearly 3 percent of brain tumors are primary central nervous system lymphomas, the various nonsurgical treatments for this disease remain unfamiliar territory to many neurologists, medical oncologists, and even experts on lymphoma. The management of the disease has drastically changed, and a growing number of patients now have a chance of a cure. Still, it is a tough disease to treat successfully. Complications of the treatment can be devastating, both in the short term and in the long
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