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Previous Volume 351:1905-1908 October 28, 2004 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The Saline versus Albumin Fluid Evaluation (SAFE) Study (May 27 issue)¹ debunks a 1998 meta-analysis associating albumin with increased mortality in critical care populations.² Regrettably, this trial may spawn a new misconception: that albumin and saline are equivalent for resuscitating a heterogeneous mix of patients in intensive care units.

Patients with trauma are generally young and healthy and should not be grouped for evaluation with older patients without trauma, many of whom have preexisting cardiopulmonary disease. The incidence of pulmonary edema is low in patients with hemorrhagic trauma, and studies have not demonstrated a benefit of albumin . . . [Full Text of this Article]

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