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Previous Volume 351:1931-1934 November 4, 2004 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Chromosome nondisjunction lands a heavy blow on the chin of humanity. The improper segregation of chromosomes during meiosis leads to chromosomally unbalanced eggs or sperm. If these gametes participate in fertilization, the outcome is an aneuploid embryo, with either trisomy (one chromosome too many) or monosomy (one chromosome too few). Since most such embryos are inviable, one might expect that these errors would be extremely rare. This is true for most organisms, but our own species is a notable exception: aneuploidy is identified in at least 5 percent of all clinically recognized pregnancies, making it the leading known cause of . . . [Full Text of this Article]

Source Information

From the Department of Human Genetics, Emory University, Atlanta (N.E.L.); and the Department of Genetics and Center for Human Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland (T.J.H.).

This article has been cited by other articles:

• Sun, F., Mikhaail-Philips, M., Oliver-Bonet, M., Ko, E., Rademaker, A., Turek, P., Martin, R.H. (2008). The relationship between meiotic recombination in human spermatocytes and aneuploidy in sperm. Hum Reprod 23: 1691-1697 [Abstract] [Full Text]  
• Zamudio, N. M, Chong, S., O'Bryan, M. K (2008). Epigenetic regulation in male germ cells. Reproduction 136: 131-146 [Abstract] [Full Text]  
• Janicke, M. A., Lasko, L., Oldenbourg, R., LaFountain, J. R. Jr (2007). Chromosome Malorientations after Meiosis II Arrest Cause Nondisjunction. Mol. Biol. Cell 18: 1645-1656 [Abstract] [Full Text]  
• Morelli, M. A, Cohen, P. E (2005). Not all germ cells are created equal: Aspects of sexual dimorphism in mammalian meiosis. Reproduction 130: 761-781 [Abstract] [Full Text]