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Previous Volume 351:2019 November 4, 2004 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Although Streubel et al. (July 15 issue)¹ provide evidence that lymphoma-associated endothelial cells have genetic changes of lymphomas, their data do not fully support this conclusion. Fluorescence in situ hybridization (FISH) studies use fluorescent probes that produce pinpoint images according to the focal plane of analysis. Nonspecific signals, characteristic of such preparations, are a potential source of false positivity. Such aberrant signals, which could falsely label endothelial cells, are not accounted for statistically in this article. Specifically, the mean and range of false positive signals of the controls are not reported.

Another concern is whether endothelial cells . . . [Full Text of this Article]

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