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Previous Volume 351:180-181 July 8, 2004 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Measurement of prostate-specific antigen (PSA) has profoundly affected virtually all clinical aspects of prostate cancer. A sharp increase in both the incidence of age-adjusted prostate cancer (about 100 percent) and the proportion of patients with early stages of the disease at the time of diagnosis (stage migration) has coincided with the advent of widespread PSA testing.^1,2,3 Moreover, there have been substantial shifts toward the use of radical prostatectomy in younger men and men with lower pretreatment PSA levels and a rising incidence of nonpalpable lesions (tumor [T] stage 1c).³ Currently, less than 10 percent of men have distant metastases at . . . [Full Text of this Article]

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From the Johns Hopkins Medical Institutions, Baltimore.

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