Heart failure is often complicated by atrial fibrillation, andatrial fibrillation can exacerbate and in some cases cause heartfailure. Adverse effects of atrial fibrillation include a lossof atrial contribution to ventricular filling, a nonphysiologicheart-rate response, irregular periods of ventricular filling,and an increased risk of thromboembolism. In an editorial inthe Journal five years ago,1 we observed that atrial fibrillationwas associated with an adverse prognosis in several studiesof heart failure, but it was not clear whether it directly increaseddisease progression and mortality or was only a marker for theseverity of heart failure. Therapy . . . [Full Text of this Article]
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From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston.
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