FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 351:2559-2560 December 9, 2004 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

To the Editor: We report an association between a rare genetic disease and both premature ovarian failure and fibrothecomas (ovarian stromal tumors). Mulibrey nanism, an autosomal recessive disorder in which growth restriction begins in utero,¹ is caused by mutations in the TRIM37 gene for a peroxisomal protein of unknown function.^2,3 Worldwide, approximately 110 patients with this disorder are known, of whom 85 are Finnish. We reviewed the hospital and autopsy reports of the 22 Finnish female postpubertal patients with mulibrey nanism; 15 had a follow-up that included a gynecologic examination, pelvic ultrasonography, and a biochemical assessment of ovarian function. Five . . . [Full Text of this Article]

This article has been cited by other articles:

• Karlberg, N., Jalanko, H., Lipsanen-Nyman, M. (2007). Growth and Growth Hormone Therapy in Subjects With Mulibrey Nanism. Pediatrics 120: e102-e111 [Abstract] [Full Text]  
• Scott, R H, Stiller, C A, Walker, L, Rahman, N (2006). Syndromes and constitutional chromosomal abnormalities associated with Wilms tumour. J. Med. Genet. 43: 705-715 [Abstract] [Full Text]