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Volume 351:2579-2580 December 16, 2004 Number 25
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Love at First Smell — The 2004 Nobel Prize in Physiology or Medicine
Peter Mombaerts, M.D., Ph.D.

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I should think we might fairly gauge the future of biological science, centuries ahead, by estimating the time it will take to reach a complete, comprehensive understanding of odor. It may not seem a profound enough problem to dominate all the life sciences, but it contains, piece by piece, all the mysteries.

— Lewis Thomas,

New England Journal of Medicine, 1980

In the spring of 1991, Linda Buck and Richard Axel reported a large family of rat genes that, they hypothesized, encoded odorant receptors.1 I was a graduate student at the time, and it was love at first sight for . . . [Full Text of this Article]


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From the Rockefeller University, New York.


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