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Previous Volume 351:2649-2651 December 16, 2004 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The oral cavity is a complex environment composed of tissues with different origins, structures, and functions. Moreover, a myriad of commensal bacteria, fungi, and viruses populate the mucosa, connective tissue, salivary glands, taste buds, bones, and teeth of the mouth. This environment is disrupted in oral mucositis (Figure 1), a serious complication of high-dose chemoradiotherapy that affects up to 75 percent of patients who undergo hematopoietic stem-cell transplantation¹ and 77 percent of patients with head and neck cancer who receive such treatment.²

View larger version (43K): [in this window] [in a new window]   Figure 1. Oral Mucositis after Chemoradiotherapy in a Patient with Leukemia, Who Was Later Treated with Bone Marrow . . . [Full Text of this Article]

 

Source Information

From the Oral Medicine Department, Hadassah University Hospital, Jerusalem, Israel.

Related Letters:

Palifermin and Chemotherapy-Induced Oral Mucositis
Awada A., Genot M.-T., Klastersky J., Köstler W. J., Hejna M., Zielinski C. C., Palmieri C., Vigushin D., Spielberger R., Stiff P., Bensinger W.
Extract | Full Text | PDF  
N Engl J Med 2005; 352:1264-1265, Mar 24, 2005. Correspondence

This article has been cited by other articles:

• McDonnell, A. M, Lenz, K. L (2007). Palifermin: Role in the Prevention of Chemotherapy- and Radiation-Induced Mucositis. The Annals of Pharmacotherapy 41: 86-94 [Abstract] [Full Text]  
• Awada, A., Genot, M.-T., Klastersky, J., Kostler, W. J., Hejna, M., Zielinski, C. C., Palmieri, C., Vigushin, D., Spielberger, R., Stiff, P., Bensinger, W. (2005). Palifermin and Chemotherapy-Induced Oral Mucositis. NEJM 352: 1264-1265 [Full Text]